Issue 49, 2017

Water-assisted metal-free catalyzed cyclization of 2-alkynylarylketones: a facile approach to indenones

Abstract

A simple and directed synthetic strategy starting from 2-alkynylarylketones was developed for the construction of various indenones under metal-free and water-assisted conditions. This intramolecular cyclization reaction could well tolerate a wide range of functional groups, and the corresponding functionalized indenones were obtained in moderate to excellent yields (up to 94%). In addition, the possible mechanism of this reaction may involve isobenzofuranium intermediates.

Graphical abstract: Water-assisted metal-free catalyzed cyclization of 2-alkynylarylketones: a facile approach to indenones

Supplementary files

Article information

Article type
Paper
Submitted
15 May 2017
Accepted
12 Jun 2017
First published
16 Jun 2017
This article is Open Access
Creative Commons BY-NC license

RSC Adv., 2017,7, 31142-31147

Water-assisted metal-free catalyzed cyclization of 2-alkynylarylketones: a facile approach to indenones

S. Zhang, X. Bai, D. Chen, P. Chen, Q. Zhang and Y. Wang, RSC Adv., 2017, 7, 31142 DOI: 10.1039/C7RA05487D

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