Issue 52, 2017, Issue in Progress
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RSC Advances

Direct C-2 acylation of indoles with toluene derivatives via Pd(ii)-catalyzed C–H activation†

Yaping Zhao,c   Upendra K. Sharma,a   Felix Schrӧder,a   Nandini Sharma,*a   Gonghua Songc  and  Erik V. Van der Eycken ORCID logo *ab  

* Corresponding authors

a Laboratory for Organic & Microwave-Assisted Chemistry (LOMAC), Department of Chemistry, University of Leuven (KU Leuven), Celestijnenlaan 200F, B-3001 Leuven, Belgium
E-mail: n_sharma023@yahoo.co.in, erik.vandereycken@chem.kuleuven.be
Web: http://chem.kuleuven.be/en/research/mds/lomac

b Peoples Friendship University of Russia (RUDN University), 6 Miklukho-Maklaya street, Moscow, Russia

c Shanghai Key Laboratory of Chemical Biology, East China University of Science and Technology, Shanghai 200237, People's Republic of China

Abstract

A simple and efficient Pd-catalyzed method for the C2-acylation of indoles is described. Less toxic, stable, and commercially available toluene derivatives were used as acyl sources, with tert-butylhydroperoxide (TBHP) as oxidant and pivalic acid as additive, providing moderate to good yields.

Graphical abstract: Direct C-2 acylation of indoles with toluene derivatives via Pd(ii)-catalyzed C–H activation

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Article information

DOI
https://doi.org/10.1039/C7RA06004A
Article type
Paper
Submitted
29 May 2017
Accepted
16 Jun 2017
First published
26 Jun 2017
This article is Open Access
Creative Commons BY license

RSC Adv., 2017,7, 32559-32563

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Direct C-2 acylation of indoles with toluene derivatives via Pd(II)-catalyzed C–H activation

Y. Zhao, U. K. Sharma, F. Schrӧder, N. Sharma, G. Song and E. V. Van der Eycken, RSC Adv., 2017, 7, 32559 DOI: 10.1039/C7RA06004A

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