Issue 86, 2017, Issue in Progress
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RSC Advances

Poly(ethylene glycol) modified Mn2+ complexes as contrast agents with a prolonged observation window in rat MRA†

Changqiang Wu, ORCID logo ab   Li Yang,a   Zhuzhong Chen,e   Houbing Zhang,a   Danyang Li,a   Bingbing Lin,a   Jiang Zhu,*c   Hua Ai*ad  and  Xiaoming Zhangb  

* Corresponding authors

a National Engineering Research Center for Biomaterials, Sichuan University, Chengdu 610064, P. R. China
E-mail: huaai@scu.edu.cn
Fax: +86-28-85413991
Tel: +86-28-85413991

b Sichuan Key Laboratory of Medical Imaging, School of Medical Imaging, North Sichuan Medical College, Nanchong 637000, P. R. China

c Sichuan Key Laboratory of Medical Imaging, Department of Chemistry, North Sichuan Medical College, Nanchong 637000, P. R. China
E-mail: zhujiang312@hotmail.com

d Department of Radiology, West China Hospital, Sichuan University, Chengdu 610041, P. R. China

e PET/CT of Imaging Department, Sichuan Cancer Hospital, Chengdu 610064, P. R. China

Abstract

A novel rigid Mn2+ complex (MnL) with pyridine and pyrrolidine rings was designed and synthesized. The complex was further modified with alkyne, and conjugated to azide-terminated PEG by click chemistry. PEGylated MnL shows considerably higher relaxivity (MnL-PEG2k-MnL: r1 = 6.38 mmol−1 s−1; MnL-PEG4.6k-MnL: r1 = 5.63 mmol−1 s−1) and much longer blood circulation time than free Mn2+ complexes (MnL: r1 = 3.73 mmol−1 s−1), providing a prolonged time window to acquire longitudinal images for rat contrast enhanced magnetic resonance angiography.

Graphical abstract: Poly(ethylene glycol) modified Mn2+ complexes as contrast agents with a prolonged observation window in rat MRA

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Article information

DOI
https://doi.org/10.1039/C7RA09975D
Article type
Paper
Submitted
07 Sep 2017
Accepted
20 Nov 2017
First published
28 Nov 2017
This article is Open Access
Creative Commons BY license

RSC Adv., 2017,7, 54603-54609

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Poly(ethylene glycol) modified Mn2+ complexes as contrast agents with a prolonged observation window in rat MRA

C. Wu, L. Yang, Z. Chen, H. Zhang, D. Li, B. Lin, J. Zhu, H. Ai and X. Zhang, RSC Adv., 2017, 7, 54603 DOI: 10.1039/C7RA09975D

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