Issue 8, 2017

Enantioselective copper catalysed, direct functionalisation of allenes via allyl copper intermediates

Abstract

The direct functionalisation of allenes under copper catalysis enables efficient access to enantioenriched, densely functionalised molecules. In this review we explore the breadth and depth of a versatile reaction manifold, which involves the element-cupration of allenes to generate allyl copper intermediates that are subsequently coupled with diverse arrays of electrophiles.

Graphical abstract: Enantioselective copper catalysed, direct functionalisation of allenes via allyl copper intermediates

Article information

Article type
Minireview
Submitted
02 May 2017
Accepted
01 Jun 2017
First published
08 Jun 2017
This article is Open Access

All publication charges for this article have been paid for by the Royal Society of Chemistry
Creative Commons BY license

Chem. Sci., 2017,8, 5240-5247

Enantioselective copper catalysed, direct functionalisation of allenes via allyl copper intermediates

A. P. Pulis, K. Yeung and D. J. Procter, Chem. Sci., 2017, 8, 5240 DOI: 10.1039/C7SC01968H

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. You can use material from this article in other publications without requesting further permissions from the RSC, provided that the correct acknowledgement is given.

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