Issue 44, 2018

Organic photocatalysis for the radical couplings of boronic acid derivatives in batch and flow

Abstract

We report an acridium-based organic photocatalyst as an efficient replacement for iridium-based photocatalysts to oxidise boronic acid derivatives by a single electron process. Furthermore, we applied the developed catalytic system to the synthesis of four active pharmaceutical ingredients (APIs). A straightforward scale up approach using continuous flow photoreactors is also reported affording gram an hour throughput.

Graphical abstract: Organic photocatalysis for the radical couplings of boronic acid derivatives in batch and flow

Supplementary files

Article information

Article type
Communication
Submitted
19 Mar 2018
Accepted
12 Apr 2018
First published
16 May 2018
This article is Open Access
Creative Commons BY license

Chem. Commun., 2018,54, 5606-5609

Organic photocatalysis for the radical couplings of boronic acid derivatives in batch and flow

F. Lima, L. Grunenberg, H. B. A. Rahman, R. Labes, J. Sedelmeier and S. V. Ley, Chem. Commun., 2018, 54, 5606 DOI: 10.1039/C8CC02169D

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