Issue 52, 2018

In vivo imaging of hepatocellular nitric oxide using a hepatocyte-targeting fluorescent sensor

Abstract

Imaging of hepatocellular nitric oxide (NO) in vivo is of great importance for understanding its roles in liver diseases, but such an imaging approach is still lacking. Herein, a hepatocyte-targeting fluorescent NO sensor has been fabricated. This sensor exhibits good water solubility, excellent selectivity, and high sensitivity (∼1.62 nM). The cells and in vivo imaging experiments reveal that Gal-RhB facilitates the visualization of hepatocellular NO in both HepG2 cells and zebrafish. These results demonstrate that Gal-RhB may be a promising tool for studying the function of NO in NO-associated liver diseases.

Graphical abstract: In vivo imaging of hepatocellular nitric oxide using a hepatocyte-targeting fluorescent sensor

Supplementary files

Article information

Article type
Communication
Submitted
22 Apr 2018
Accepted
05 Jun 2018
First published
05 Jun 2018

Chem. Commun., 2018,54, 7231-7234

In vivo imaging of hepatocellular nitric oxide using a hepatocyte-targeting fluorescent sensor

P. Zhang, Y. Tian, H. Liu, J. Ren, H. Wang, R. Zeng, Y. Long and J. Chen, Chem. Commun., 2018, 54, 7231 DOI: 10.1039/C8CC03240H

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