Issue 59, 2018

Supramolecular chemotherapeutic drug constructed from pillararene-based supramolecular amphiphile

Abstract

Based on the host–guest interaction between a CPT-conjugated prodrug amphiphile (CPT-ss-Py) and a water-soluble pillar[5]arene (P5), a GSH-responsive supramolecular chemotherapeutic drug (P5⊃CPT-ss-Py) was fabricated. Through this supramolecular formulation, internalization and anticancer efficacy were greatly increased.

Graphical abstract: Supramolecular chemotherapeutic drug constructed from pillararene-based supramolecular amphiphile

Supplementary files

Article information

Article type
Communication
Submitted
31 May 2018
Accepted
21 Jun 2018
First published
22 Jun 2018

Chem. Commun., 2018,54, 8198-8201

Supramolecular chemotherapeutic drug constructed from pillararene-based supramolecular amphiphile

D. Wu, Y. Li, J. Shen, Z. Tong, Q. Hu, L. Li and G. Yu, Chem. Commun., 2018, 54, 8198 DOI: 10.1039/C8CC04334E

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