Issue 83, 2018

Encoding function into polypeptide-oligonucleotide precision biopolymers

Abstract

We report a novel synthesis strategy to prepare precision polymers providing exact chain lengths, molecular weights and monomer sequences that allow post modifications by convenient DNA hybridization. Two grafted single strand DNA (ssDNA) side chains serve as a versatile platform for sequence-specific attachment of chromophores, proteins, cell-targeting peptide, and a Y-shape DNA linker. This approach resembles a LEGO®-type incorporation of functionalities to create functional biopolymers of high structure definition under mild conditions.

Graphical abstract: Encoding function into polypeptide-oligonucleotide precision biopolymers

Supplementary files

Article information

Article type
Communication
Submitted
13 Jun 2018
Accepted
21 Sep 2018
First published
26 Sep 2018
This article is Open Access
Creative Commons BY license

Chem. Commun., 2018,54, 11797-11800

Encoding function into polypeptide-oligonucleotide precision biopolymers

W. Liu, F. Boldt, Y. Tokura, T. Wang, B. K. Agrawalla, Y. Wu and T. Weil, Chem. Commun., 2018, 54, 11797 DOI: 10.1039/C8CC04725A

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. You can use material from this article in other publications without requesting further permissions from the RSC, provided that the correct acknowledgement is given.

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