Issue 70, 2018

Turning off Bacillus cereus quorum sensing system with peptidic analogs

Abstract

We explored quenching of the PlcR–PapR quorum-sensing system in Bacillus cereus. We generated PapR7-peptidic derivatives that inhibit this system and thus the production of virulence factors, reflected by a loss in hemolytic activity, without affecting bacterial growth. To our knowledge, these peptides represent the first potent synthetic inhibitors of quorum-sensing in B. cereus.

Graphical abstract: Turning off Bacillus cereus quorum sensing system with peptidic analogs

Supplementary files

Article information

Article type
Communication
Submitted
09 Jul 2018
Accepted
01 Aug 2018
First published
14 Aug 2018

Chem. Commun., 2018,54, 9777-9780

Turning off Bacillus cereus quorum sensing system with peptidic analogs

A. Yehuda, L. Slamti, R. Bochnik-Tamir, E. Malach, D. Lereclus and Z. Hayouka, Chem. Commun., 2018, 54, 9777 DOI: 10.1039/C8CC05496G

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