Issue 82, 2018
From the journal:

Chemical Communications

DNA-Mediated rolling circle amplification for ultrasensitive detection of thrombin using MALDI-TOF mass spectrometry†

Zengnan Wu, ORCID logo ‡ab   Ling Lin, ORCID logo ‡*c   Mashooq Khan, ORCID logo b   Weifei Zhang,b   Sifeng Mao, ORCID logo b   Yajing Zheng,b   Zenghe Lia  and  Jin-Ming Lin ORCID logo *b  

* Corresponding authors

a State Key Laboratory of Chemical Resource Engineering, Beijing University of Chemical Technology, Beijing, China

b Department of Chemistry, Beijing Key Laboratory of Micronalytical Methods and Instrumentation, MOE Key Laboratory of Bioorganic Phosphorus Chemistry & Chemical Biology, Tsinghua University, Beijing 100084, China
E-mail: jmlin@mail.tsinghua.edu.cn

c CAS Key Laboratory of Standardization and Measurement for Nanotechnology, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology, Beijing, China
E-mail: linling@nanoctr.cn

Abstract

A DNA-mediated rolling circle amplification (RCA) strategy was established for ultrasensitive and specific detection of thrombin via matrix-assisted laser desorption ionization time-of-flight mass spectrometry (MALDI-TOF MS). This platform provides a versatile assay for the detection of various biomolecules of low abundance.

Graphical abstract: DNA-Mediated rolling circle amplification for ultrasensitive detection of thrombin using MALDI-TOF mass spectrometry

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Article information

DOI
https://doi.org/10.1039/C8CC06934D
Article type
Communication
Submitted
26 Aug 2018
Accepted
21 Sep 2018
First published
21 Sep 2018

Chem. Commun., 2018,54, 11546-11549

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DNA-Mediated rolling circle amplification for ultrasensitive detection of thrombin using MALDI-TOF mass spectrometry

Z. Wu, L. Lin, M. Khan, W. Zhang, S. Mao, Y. Zheng, Z. Li and J. Lin, Chem. Commun., 2018, 54, 11546 DOI: 10.1039/C8CC06934D

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