Issue 95, 2018

Use of an NIR-light-responsive CO nanodonor to improve the EPR effect in photothermal cancer treatment

Abstract

The carbon monoxide (CO)-carrying palladium nanosheet (PdNS-CO) was exploited as a photothermally triggered donor of CO. Irradiating material containing PdNS-CO with 808 nm-wavelength light caused a rapid heating of the material, triggering a release of CO. The enhanced permeability and retention (EPR) effect was found to be improved by such released CO and resulted in an increase in the accumulation of PdNS-CO at tumors and hence promoted its use in photothermal therapy (PTT) using a low laser power density.

Graphical abstract: Use of an NIR-light-responsive CO nanodonor to improve the EPR effect in photothermal cancer treatment

Supplementary files

Article information

Article type
Communication
Submitted
02 Oct 2018
Accepted
01 Nov 2018
First published
02 Nov 2018

Chem. Commun., 2018,54, 13403-13406

Use of an NIR-light-responsive CO nanodonor to improve the EPR effect in photothermal cancer treatment

C. Wang, Y. Li, X. Shi, J. Zhou, L. Zhou and S. Wei, Chem. Commun., 2018, 54, 13403 DOI: 10.1039/C8CC07873D

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