Issue 96, 2018

Palladium catalyzed selective arylation of o-carboranes via B(4)–H activation: amide induced regioselectivity reversal

Abstract

By changing the charge distribution of boron vertices via introducing an amide on cage B(9), the selective B(4) arylation of o-carboranes via Suzuki–Miyaura coupling has been developed. A series of o-carborane derivatives decorated with diverse active groups have been synthesized with moderate to good yields, which have been proved to be further transformed to a novel kind of tri-substituted nido-carborane fused oxazole with potential application in boron neutron capture therapy, organometallic as well as coordination chemistry.

Graphical abstract: Palladium catalyzed selective arylation of o-carboranes via B(4)–H activation: amide induced regioselectivity reversal

Supplementary files

Article information

Article type
Communication
Submitted
12 Oct 2018
Accepted
14 Nov 2018
First published
14 Nov 2018

Chem. Commun., 2018,54, 13603-13606

Palladium catalyzed selective arylation of o-carboranes via B(4)–H activation: amide induced regioselectivity reversal

T. Xu, K. Cao, C. Zhang, J. Wu, L. Jiang and J. Yang, Chem. Commun., 2018, 54, 13603 DOI: 10.1039/C8CC08193J

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