Issue 18, 2019
From the journal:

Chemical Communications

Mitochondria targeted and NADH triggered photodynamic activity of chloromethyl modified Ru(ii) complexes under hypoxic conditions†

Na Tian,ab   Weize Sun,ab   Xusheng Guo,ab   Jian Lu,ab   Chao Li,a   Yuanjun Hou,a   Xuesong Wang ORCID logo *ab  and  Qianxiong Zhou ORCID logo *a  

* Corresponding authors

a Key Laboratory of Photochemical Conversion and Optoelectronic Materials, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing 100190, P. R. China
E-mail: xswang@mail.ipc.ac.cn, zhouqianxiong@mail.ipc.ac.cn
Fax: +86-10-62564049
Tel: +86-10-82543592

b University of Chinese Academy of Sciences, Beijing 100049, P. R. China

Abstract

Three chloromethyl-modified Ru(II) complexes were designed and synthesized as mitochondria targeting photosensitizers, which can generate carbon radicals in the presence of NADH under visible light irradiation, cause DNA cleavage and covalent binding in Ar-saturated solutions, and lead to apoptosis of human ovarian carcinoma SKOV-3 cells under hypoxic conditions (3% O2), demonstrating a new mode of type I mechanism to overcome the limitation of hypoxia in photodynamic therapy (PDT).

Graphical abstract: Mitochondria targeted and NADH triggered photodynamic activity of chloromethyl modified Ru(ii) complexes under hypoxic conditions

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Article information

DOI
https://doi.org/10.1039/C8CC09186B
Article type
Communication
Submitted
19 Nov 2018
Accepted
01 Feb 2019
First published
12 Feb 2019

Chem. Commun., 2019,55, 2676-2679

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Mitochondria targeted and NADH triggered photodynamic activity of chloromethyl modified Ru(II) complexes under hypoxic conditions

N. Tian, W. Sun, X. Guo, J. Lu, C. Li, Y. Hou, X. Wang and Q. Zhou, Chem. Commun., 2019, 55, 2676 DOI: 10.1039/C8CC09186B

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