Issue 6, 2019
From the journal:

Chemical Communications

Iridium-catalyzed 1,5-(aryl)aminomethylation of 1,3-enynes by alkenyl-to-allyl 1,4-iridium(i) migration†

Rebecca E. Ruscoe, ORCID logo ab   Michael Callingham,ab   Joshua A. Baker,ab   Stamatis E. Korkis ORCID logo ab  and  Hon Wai Lam ORCID logo *ab  

* Corresponding authors

a The GlaxoSmithKline Carbon Neutral Laboratories for Sustainable Chemistry, University of Nottingham, Jubilee Campus, Triumph Road, Nottingham, UK
E-mail: hon.lam@nottingham.ac.uk

b School of Chemistry, University of Nottingham, University Park, Nottingham, UK

Abstract

A novel multicomponent coupling reaction involving the iridium-catalyzed 1,5-difunctionalization of 1,3-enynes with arylboronic acids and triazinanes is described. A key step in this 1,5-(aryl)aminomethylation reaction is the alkenyl-to-allyl 1,4-iridium(I) migration.

Graphical abstract: Iridium-catalyzed 1,5-(aryl)aminomethylation of 1,3-enynes by alkenyl-to-allyl 1,4-iridium(i) migration

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Article information

DOI
https://doi.org/10.1039/C8CC09238A
Article type
Communication
Submitted
20 Nov 2018
Accepted
14 Dec 2018
First published
14 Dec 2018

Chem. Commun., 2019,55, 838-841

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Iridium-catalyzed 1,5-(aryl)aminomethylation of 1,3-enynes by alkenyl-to-allyl 1,4-iridium(I) migration

R. E. Ruscoe, M. Callingham, J. A. Baker, S. E. Korkis and H. W. Lam, Chem. Commun., 2019, 55, 838 DOI: 10.1039/C8CC09238A

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