Issue 7, 2019

Enzyme-like substrate-selectivity in C–H oxidation enabled by recognition

Abstract

Substrate-selectivity stemming from recognition is a key feature of enzymes that has been seldom observed in artificial catalysts. Herein, we report a recognition-driven, substrate-selective C–H oxidation that inverts the intrinsic reactivity of the competing C–H bonds. Analysis of this selectivity highlights an unexpectedly high reactivity enhancement imparted by intramolecularity.

Graphical abstract: Enzyme-like substrate-selectivity in C–H oxidation enabled by recognition

Supplementary files

Article information

Article type
Communication
Submitted
23 Nov 2018
Accepted
20 Dec 2018
First published
21 Dec 2018

Chem. Commun., 2019,55, 917-920

Enzyme-like substrate-selectivity in C–H oxidation enabled by recognition

G. Olivo, G. Capocasa, O. Lanzalunga, S. Di Stefano and M. Costas, Chem. Commun., 2019, 55, 917 DOI: 10.1039/C8CC09328H

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