Issue 24, 2018

A guide to maximizing the therapeutic potential of protein–polymer conjugates by rational design

Abstract

Proteins are an important class of therapeutics that have advantages including high target specificity, but challenges to their use include rapid clearance and low physical stability. Conjugation of synthetic polymers is an effective approach to address the drawbacks and enhance other properties such as solubility. In this review, we present various considerations in synthesizing protein–polymer conjugates for therapeutic applications with a focus on the choice of polymer, protein, and conjugation method, as well as characterization and evaluation of the resulting conjugate in order to maximize the therapeutic potential of the protein drug.

Graphical abstract: A guide to maximizing the therapeutic potential of protein–polymer conjugates by rational design

Article information

Article type
Tutorial Review
Submitted
28 Jul 2018
First published
16 Nov 2018

Chem. Soc. Rev., 2018,47, 8998-9014

A guide to maximizing the therapeutic potential of protein–polymer conjugates by rational design

J. H. Ko and H. D. Maynard, Chem. Soc. Rev., 2018, 47, 8998 DOI: 10.1039/C8CS00606G

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