Issue 45, 2018

Interfacially synthesized Fe-soc-MOF nanoparticles combined with ICG for photothermal/photodynamic therapy

Abstract

Recently, fabrication of nanoscale MOFs (NMOFs) has attracted great attention for biomedical applications. NMOFs not only maintain the structural diversity and physicochemical properties of bulk MOFs, but also possess suitable dimensions, making them potential nanocarriers for imaging agents and drug molecules. In this work, highly monodispersed Fe-soc-MOF nanoparticles (about 100 nm) were fabricated through the liquid–solid–solution (LSS) method. Indocyanine green (ICG) was conjugated to the surface-modified Fe-soc-MOF to construct a multifunctional theranostic platform. The Fe-soc-MOF@PEG-NH2-ICG nanoparticles (FPINs) were tested for photothermal therapy (PTT)/photodynamic therapy (PDT) both in vitro and in vivo. Due to their low toxicity, good biocompatibility and excellent photothermal/photodynamic effect, the as-synthesized FPINs could be used to inhibit and kill cancer cells efficiently under the 808 nm laser irradiation.

Graphical abstract: Interfacially synthesized Fe-soc-MOF nanoparticles combined with ICG for photothermal/photodynamic therapy

Supplementary files

Article information

Article type
Paper
Submitted
19 Jul 2018
Accepted
19 Oct 2018
First published
19 Oct 2018

Dalton Trans., 2018,47, 16329-16336

Interfacially synthesized Fe-soc-MOF nanoparticles combined with ICG for photothermal/photodynamic therapy

X. Cai, B. Liu, M. Pang and J. Lin, Dalton Trans., 2018, 47, 16329 DOI: 10.1039/C8DT02941E

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