Volume 211, 2018
From the journal:

Faraday Discussions

How many ritonavir cases are there still out there?

Marcus A. Neumann*a  and  Jacco van de Streek ORCID logo a  

* Corresponding authors

a Avant-garde Materials Simulation, Alte Str. 2, 79249 Merzhausen, Germany
E-mail: marcus.neumann@avmatsim.eu

Abstract

Based on a thorough and critical analysis of the commercial crystal structure prediction studies of 41 pharmaceutical compounds, we conclude that for between 15 and 45% of all small-molecule drugs currently on the market the most stable experimentally observed polymorph is not the thermodynamically most stable crystal structure and that the appearance of the latter is kinetically hindered.

Graphical abstract: How many ritonavir cases are there still out there?

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Article information

DOI
https://doi.org/10.1039/C8FD00069G
Article type
Paper
Submitted
26 Mar 2018
Accepted
30 Apr 2018
First published
17 May 2018
This article is Open Access
Creative Commons BY-NC license

Faraday Discuss., 2018,211, 441-458

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How many ritonavir cases are there still out there?

M. A. Neumann and J. van de Streek, Faraday Discuss., 2018, 211, 441 DOI: 10.1039/C8FD00069G

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