Issue 21, 2018

Copper catalysis: ligand-controlled selective N-methylation or N-formylation of amines with CO2 and phenylsilane

Abstract

Cupric subcarbonate (Cu2(OH)2CO3) was found to be effective for the reductive functionalization of CO2 to produce formamides and methylamines with phenylsilane as reductant. Interestingly, N-formylation and N-methylation were switched on/off by subtly choosing the ligand: DPPB (1,4-bis(diphenylphosphino)butane) promoted N-methylation whereas Ph2CyP (diphenylcyclohexylphosphine) favored for N-formylation.

Graphical abstract: Copper catalysis: ligand-controlled selective N-methylation or N-formylation of amines with CO2 and phenylsilane

Supplementary files

Article information

Article type
Communication
Submitted
22 Jul 2018
Accepted
18 Sep 2018
First published
18 Sep 2018

Green Chem., 2018,20, 4853-4858

Copper catalysis: ligand-controlled selective N-methylation or N-formylation of amines with CO2 and phenylsilane

X. Li, S. Xia, K. Chen, X. Liu, H. Li and L. He, Green Chem., 2018, 20, 4853 DOI: 10.1039/C8GC02280A

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