Issue 11, 2019

Photophysical properties and photodynamic therapy activity of a meso-tetra(4-carboxyphenyl)porphyrin tetramethyl ester–graphene quantum dot conjugate

Abstract

Novel meso-tetra(4-carboxyphenyl)porphyrin tetramethyl ester metal derivatives were synthesised and characterized. These derivatives were interacted with graphene quantum dots (GDQs). Spectroscopic evidence that was obtained showed that the resultant conjugates were stable due to the strong π–π stacking interaction between the GQDs and the porphyrins. The fluorescence and singlet oxygen generating behaviour of the porphyrins and the nanoconjugates were investigated following incorporation. The dark toxicity and photodynamic therapy activities of the porphyrins and the nanoconjugates were successfully studied using MCF-7 breast cancer cells. Cell viability for the dark toxicity was more than 90% for all complexes. The PDT activities at the highest concentration of 120 μg ml−1 showed a decrease in cell viability down to 15.2% for the GaClTMPP–GQDs.

Graphical abstract: Photophysical properties and photodynamic therapy activity of a meso-tetra(4-carboxyphenyl)porphyrin tetramethyl ester–graphene quantum dot conjugate

Supplementary files

Article information

Article type
Paper
Submitted
06 Dec 2018
Accepted
16 Feb 2019
First published
26 Feb 2019

New J. Chem., 2019,43, 4518-4524

Photophysical properties and photodynamic therapy activity of a meso-tetra(4-carboxyphenyl)porphyrin tetramethyl ester–graphene quantum dot conjugate

M. Managa, B. P. Ngoy and T. Nyokong, New J. Chem., 2019, 43, 4518 DOI: 10.1039/C8NJ06175K

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