Issue 2, 2019

2-Formylpyrrole natural products: origin, structural diversity, bioactivity and synthesis

Abstract

Covering: up to April 2018

2-Formylpyrroles are ubiquitous in nature, arising from the non-enzymatic Maillard reactions of amines and sugars. Often confused for secondary metabolites, these Maillard products display interesting biological activities including hepatoprotective, immunostimulatory, antiproliferative and antioxidant effects. This review presents all 2-formylpyrrole natural products reported to date and identifies structural sub-classes for their categorisation. The origin, biological activity and chemical syntheses of these natural products are discussed herein.

Graphical abstract: 2-Formylpyrrole natural products: origin, structural diversity, bioactivity and synthesis

Article information

Article type
Review Article
Submitted
13 Jun 2018
First published
24 Jul 2018
This article is Open Access
Creative Commons BY license

Nat. Prod. Rep., 2019,36, 289-306

2-Formylpyrrole natural products: origin, structural diversity, bioactivity and synthesis

James M. Wood, D. P. Furkert and M. A. Brimble, Nat. Prod. Rep., 2019, 36, 289 DOI: 10.1039/C8NP00051D

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. You can use material from this article in other publications without requesting further permissions from the RSC, provided that the correct acknowledgement is given.

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