An effective preparation of both 1,3-diketones and nitriles from alkynones with oximes as hydroxide sources†
Abstract
An effective phosphine-catalyzed protocol has been established for the syntheses of 1,3-diketones and nitriles from alkynones with oximes as hydroxide surrogates. This method features the use of a phosphine catalyst, compatibility with various functional groups and ambient temperature, which makes this approach very practical. A plausible mechanism was proposed.
- This article is part of the themed collection: Synthetic methodology in OBC