Issue 37, 2018

An effective preparation of both 1,3-diketones and nitriles from alkynones with oximes as hydroxide sources

Abstract

An effective phosphine-catalyzed protocol has been established for the syntheses of 1,3-diketones and nitriles from alkynones with oximes as hydroxide surrogates. This method features the use of a phosphine catalyst, compatibility with various functional groups and ambient temperature, which makes this approach very practical. A plausible mechanism was proposed.

Graphical abstract: An effective preparation of both 1,3-diketones and nitriles from alkynones with oximes as hydroxide sources

Supplementary files

Article information

Article type
Paper
Submitted
01 Aug 2018
Accepted
31 Aug 2018
First published
03 Sep 2018

Org. Biomol. Chem., 2018,16, 8336-8344

An effective preparation of both 1,3-diketones and nitriles from alkynones with oximes as hydroxide sources

P. Chen, Q. Zhang, J. Guo, L. Chen, Y. Wang and X. Zhang, Org. Biomol. Chem., 2018, 16, 8336 DOI: 10.1039/C8OB01861H

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements