Issue 42, 2018
From the journal:

Organic & Biomolecular Chemistry

Step-economical synthesis of 3-amido-2-quinolones by dendritic copper powder-mediated one-pot reaction†

Byung Hoon Ahn,ab   Ill Young Leea  and  Hee Nam Lim ORCID logo *a  

* Corresponding authors

a Eco-Friendly New Materials Research Center, Therapeutics&Biotechnology Division, Korea Research Institute of Chemical Technology (KRICT), 141 Gajeong-ro, Yuseong-gu, Daejeon 34114, Republic of Korea
E-mail: heenam@krict.re.kr

b Department of Chemistry, Korea University, 145 Anam-ro, Seongbuk-Gu, Seoul 02841, Republic of Korea

Abstract

The one-pot protocol by the dendritic copper powder-mediated Knoevenagel condensation/annelation is delineated here for the synthesis of 3-amido-2-quinolones. It is practical with moisture tolerance and easy setup, and is compatible with many functional groups under mild conditions. This method was applied for the preparation of the key intermediates of biologically relevant 3-amido-2-quinolones.

Graphical abstract: Step-economical synthesis of 3-amido-2-quinolones by dendritic copper powder-mediated one-pot reaction

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Article information

DOI
https://doi.org/10.1039/C8OB01994K
Article type
Paper
Submitted
15 Aug 2018
Accepted
01 Oct 2018
First published
02 Oct 2018

Org. Biomol. Chem., 2018,16, 7851-7860

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Step-economical synthesis of 3-amido-2-quinolones by dendritic copper powder-mediated one-pot reaction

B. H. Ahn, I. Y. Lee and H. N. Lim, Org. Biomol. Chem., 2018, 16, 7851 DOI: 10.1039/C8OB01994K

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