Issue 2, 2019

AgBF4-catalyzed deoxygenative C2-amination of quinoline N-oxides with isothiocyanates

Abstract

A general, effective and convenient protocol for the direct synthesis of various 2-aminoquinolines (39 examples) through AgBF4-catalyzed amination of quinoline N-oxides with isothiocyanates under base-, oxidant-free and mild conditions was developed. The transformation could be performed on a gram-scale and in a sequential manner starting from quinoline N-oxide to the synthesis of benzo[4,5]imidazo[1,2-a]quinoline.

Graphical abstract: AgBF4-catalyzed deoxygenative C2-amination of quinoline N-oxides with isothiocyanates

Supplementary files

Article information

Article type
Research Article
Submitted
18 Oct 2018
Accepted
15 Nov 2018
First published
16 Nov 2018

Org. Chem. Front., 2019,6, 167-171

AgBF4-catalyzed deoxygenative C2-amination of quinoline N-oxides with isothiocyanates

L. Xie, S. Peng, L. Jiang, X. Peng, W. Xia, X. Yu, X. Wang, Z. Cao and W. He, Org. Chem. Front., 2019, 6, 167 DOI: 10.1039/C8QO01128A

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