Issue 49, 2018, Issue in Progress
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RSC Advances

Harzianumnones A and B: two hydroxyanthraquinones from the coral-derived fungus Trichoderma harzianum†

Ting Shi,ab   Xue-Mei Hou,ab   Zhi-Yong Li,c   Fei Cao,d   Ya-Hui Zhang,ab   Jia-Yin Yu,ab   Dong-Lin Zhao,ab   Chang-Lun Shao*ab  and  Chang-Yun Wang ORCID logo *abe  

* Corresponding authors

a Key Laboratory of Marine Drugs, The Ministry of Education of China, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, People's Republic of China
E-mail: changyun@ouc.edu.cn
Tel: +86-532-8203-1536

b Laboratory for Marine Drugs and Bioproducts, Qingdao National Laboratory for Marine Science and Technology, Qingdao 266071, People's Republic of China

c Marine Biotechnology Laboratory, State Key Laboratory of Microbial Metabolism, School of Life Sciences & Biotechnology, Shanghai Jiao Tong University, Shanghai 200240, People's Republic of China

d Key Laboratory of Pharmaceutical Quality Control of Hebei Province, College of Pharmaceutical Sciences, Hebei University, Baoding 071002, People's Republic of China

e Institute of Evolution & Marine Biodiversity, Ocean University of China, Qingdao 266003, People's Republic of China

Abstract

Two new hydroxyanthraquinones, harzianumnones A (1) and B (2), together with seven known analogs (3–9), were isolated from the soft coral-derived fungus Trichoderma harzianum (XS-20090075). Their chemical structures were elucidated by extensive spectroscopic investigation. The absolute configurations of 1 and 2 were determined by ECD calculation and single-crystal X-ray diffraction. Compounds 1 and 2 were identified as a pair of epimers, which are the first example of hydroanthraquinones from T. harzianum. Compounds 7 and 8 exhibited cytotoxicity against hepatoma cell line HepG2 with IC50 values of 2.10 and 9.39 μM, respectively. Compound 7 was still found to show cytotoxicity against cervical cancer cell line HeLa with an IC50 value of 8.59 μM.

Graphical abstract: Harzianumnones A and B: two hydroxyanthraquinones from the coral-derived fungus Trichoderma harzianum

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Article information

DOI
https://doi.org/10.1039/C8RA04865G
Article type
Paper
Submitted
07 Jun 2018
Accepted
20 Jul 2018
First published
02 Aug 2018
This article is Open Access
Creative Commons BY-NC license

RSC Adv., 2018,8, 27596-27601

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Harzianumnones A and B: two hydroxyanthraquinones from the coral-derived fungus Trichoderma harzianum

T. Shi, X. Hou, Z. Li, F. Cao, Y. Zhang, J. Yu, D. Zhao, C. Shao and C. Wang, RSC Adv., 2018, 8, 27596 DOI: 10.1039/C8RA04865G

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