Issue 72, 2018

Cu-catalyzed cross-coupling reactions of vinyl epoxide with organoboron compounds: access to homoallylic alcohols

Abstract

Copper-catalyzed cross-coupling reactions of vinyl epoxide with arylboronates to obtain aryl-substituted homoallylic alcohols are described. The reaction selectivity was different to that of previously reported vinyl epoxide ring-opening reactions using aryl nucleophiles. The reaction proceeded under mild conditions, affording aryl-substituted homoallylic alcohols with high selectivity and in good to excellent yields. The reaction provides convenient access to aryl-substituted homoallylic alcohols from vinyl epoxide

Graphical abstract: Cu-catalyzed cross-coupling reactions of vinyl epoxide with organoboron compounds: access to homoallylic alcohols

Supplementary files

Article information

Article type
Paper
Submitted
01 Nov 2018
Accepted
28 Nov 2018
First published
12 Dec 2018
This article is Open Access
Creative Commons BY license

RSC Adv., 2018,8, 41561-41565

Cu-catalyzed cross-coupling reactions of vinyl epoxide with organoboron compounds: access to homoallylic alcohols

X. Lu, J. Li, J. Wang, S. Wang, Y. Li, Y. Zhu, R. Zhou and W. Ma, RSC Adv., 2018, 8, 41561 DOI: 10.1039/C8RA09048C

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. You can use material from this article in other publications without requesting further permissions from the RSC, provided that the correct acknowledgement is given.

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