Issue 44, 2018

Palladium(ii)-catalyzed γ-selective hydroarylation of alkenyl carbonyl compounds with arylboronic acids

Abstract

A catalytic γ-selective syn-hydroarylation of alkenyl carbonyl compounds using arylboronic acids has been developed using a substrate directivity approach with a palladium(II) catalyst. This method tolerates a wide range of functionalized (hetero)arylboronic acids and a variety of substitution patterns on the alkene. Preliminary mechanistic studies suggest that transmetalation is rate-limiting.

Graphical abstract: Palladium(ii)-catalyzed γ-selective hydroarylation of alkenyl carbonyl compounds with arylboronic acids

Supplementary files

Article information

Article type
Edge Article
Submitted
12 Jul 2018
Accepted
31 Aug 2018
First published
06 Sep 2018
This article is Open Access

All publication charges for this article have been paid for by the Royal Society of Chemistry
Creative Commons BY-NC license

Chem. Sci., 2018,9, 8363-8368

Palladium(II)-catalyzed γ-selective hydroarylation of alkenyl carbonyl compounds with arylboronic acids

R. Matsuura, T. C. Jankins, D. E. Hill, K. S. Yang, G. M. Gallego, S. Yang, M. He, F. Wang, R. P. Marsters, I. McAlpine and K. M. Engle, Chem. Sci., 2018, 9, 8363 DOI: 10.1039/C8SC03081B

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