Issue 16, 2019

Multiwalled carbon nanotubes for combination therapy: a biodistribution and efficacy pilot study

Abstract

A drug delivery system (DDS) for combined therapy, based on a short oxidized multiwalled carbon nanotube, is reported. It was prepared by exploiting a synthetic approach which allowed loading of two drugs, doxorubicin and metformin, the targeting agent biotin and a radiolabeling tag, to enable labeling with Ga-68 or Cu-64 in order to perform an extensive biodistribution study by PET/CT. The DDS biodistribution profile changes with different administration methods. Once administered at therapeutic doses, the DDS showed a marginal beneficial effect on 4T1 tumor bearing mice, a syngeneic and orthotopic model of triple negative breast cancer, with survival extended by 1 week and 2 days in 20% of the mice. This is encouraging given the aggressiveness of the 4T1 tumor. Furthermore, our DDS was well tolerated, ruling out concerns regarding the toxicity of carbon nanotubes.

Graphical abstract: Multiwalled carbon nanotubes for combination therapy: a biodistribution and efficacy pilot study

Supplementary files

Article information

Article type
Paper
Submitted
18 Dec 2018
Accepted
06 Mar 2019
First published
12 Mar 2019

J. Mater. Chem. B, 2019,7, 2678-2687

Multiwalled carbon nanotubes for combination therapy: a biodistribution and efficacy pilot study

G. Biagiotti, F. Pisaneschi, S. T. Gammon, F. Machetti, M. C. Ligi, G. Giambastiani, G. Tuci, E. Powell, H. Piwnica-Worms, E. Pranzini, P. Paoli, S. Cicchi and D. Piwnica-Worms, J. Mater. Chem. B, 2019, 7, 2678 DOI: 10.1039/C8TB03299H

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