Issue 32, 2019
From the journal:

Chemical Communications

A lysosome-targeting and polarity-specific fluorescent probe for cancer diagnosis†

Li Fan, ORCID logo ‡*a   Xiaodong Wang,‡a   Jinyin Ge,a   Feng Li, ORCID logo *b   Xiao Wang,c   Juanjuan Wang,d   Shaomin Shuang ORCID logo a  and  Chuan Dong ORCID logo *a  

* Corresponding authors

a Institute of Environmental Science, College of Chemistry and Chemical Engineering, Shanxi University, Taiyuan, P. R. China
E-mail: fanli128@sxu.edu.cn, dc@sxu.edu.cn

b Department of Chemistry, Centre for Biotechnology, Brock University, St. Catharines, Ontario, Canada
E-mail: fli@brocku.ca

c Taiyuan Central Hospital, Taiyuan, P. R. China

d Scientific Instrument Center, Shanxi University, Taiyuan, P. R. China

Abstract

A lysosome-targeting and polarity-specific fluorescent probe CPM has been rationally designed for cancer diagnosis and imaging. We have successfully shown that lysosome polarity may serve as an ubiquitious marker for cancer detection. The potential of CPM for cancer diagnosis has also been demonstrated at the levels of live cells, organs, whole animal, and clinical patient tissue samples.

Graphical abstract: A lysosome-targeting and polarity-specific fluorescent probe for cancer diagnosis

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Article information

DOI
https://doi.org/10.1039/C9CC00962K
Article type
Communication
Submitted
01 Feb 2019
Accepted
26 Mar 2019
First published
27 Mar 2019

Chem. Commun., 2019,55, 4703-4706

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A lysosome-targeting and polarity-specific fluorescent probe for cancer diagnosis

L. Fan, X. Wang, J. Ge, F. Li, X. Wang, J. Wang, S. Shuang and C. Dong, Chem. Commun., 2019, 55, 4703 DOI: 10.1039/C9CC00962K

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