Issue 28, 2019
From the journal:

Chemical Communications

A free radical alkylation of quinones with olefins†

Shuai Liu,ab   Tong Shen,a   Zaigang Luo ORCID logo a  and  Zhong-Quan Liu ORCID logo *b  

* Corresponding authors

a College of Chemical Engineering, Anhui University of Science and Technology, Huainan, Anhui 232001, P. R. China

b State Key Laboratory Cultivation Base for TCM Quality and Efficacy, College of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023, P. R. China
E-mail: liuzhq@lzu.edu.cn

Abstract

We demonstrated herein an Fe(III)-mediated radical alkylation of quinones. A wide range of bioactive molecules with quinone motifs can be rapidly synthesized by using readily available and inexpensive NaBH4/NaBD4 with alkenes at room temperature under open flask conditions.

Graphical abstract: A free radical alkylation of quinones with olefins

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Article information

DOI
https://doi.org/10.1039/C9CC01704F
Article type
Communication
Submitted
01 Mar 2019
Accepted
12 Mar 2019
First published
12 Mar 2019

Chem. Commun., 2019,55, 4027-4030

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A free radical alkylation of quinones with olefins

S. Liu, T. Shen, Z. Luo and Z. Liu, Chem. Commun., 2019, 55, 4027 DOI: 10.1039/C9CC01704F

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