Issue 37, 2019

Mapping aldehydic load in vivo by positron emission tomography with [18F]NA3BF3

Abstract

A new radiotracer, [18F]NA3BF3, capable of rapid, stable, and catalyst-free complexation of aldehydes in vivo is reported. [18F]NA3BF3 was shown to bind aldehydes in live subjects using locally administered aldehyde-presenting microparticles, and was then applied to mapping aldehydic load in a mouse model of sepsis. [18F]NA3BF3 may enable the direct investigation of the chemical biology of aldehydes in living subjects, and may open avenues for the adoption of endogenous aldehydic load as an imaging biomarker of inflammatory pathology.

Graphical abstract: Mapping aldehydic load in vivo by positron emission tomography with [18F]NA3BF3

Supplementary files

Article information

Article type
Communication
Submitted
06 Mar 2019
Accepted
10 Apr 2019
First published
11 Apr 2019

Chem. Commun., 2019,55, 5371-5374

Mapping aldehydic load in vivo by positron emission tomography with [18F]NA3BF3

A. Kirby, M. Suchý, A. Brouwer and A. Shuhendler, Chem. Commun., 2019, 55, 5371 DOI: 10.1039/C9CC01831J

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements