Issue 50, 2019

Photo-accelerated “click” reaction between diarylsydnones and ring-strained alkynes for bioorthogonal ligation

Abstract

We constructed a library of diarylsydnone (DASyd) candidates in search of a photoclickable reaction toward alkynes, enabling an ultra-accelerated reactivity, while suppressing the background cycloaddition in the dark. The in vitro and in vivo protein labelling experiments revealed that the photo-accelerated DASyd–alkyne cycloaddition exhibits robust selectivity.

Graphical abstract: Photo-accelerated “click” reaction between diarylsydnones and ring-strained alkynes for bioorthogonal ligation

Supplementary files

Article information

Article type
Communication
Submitted
13 Apr 2019
Accepted
23 May 2019
First published
24 May 2019

Chem. Commun., 2019,55, 7187-7190

Photo-accelerated “click” reaction between diarylsydnones and ring-strained alkynes for bioorthogonal ligation

X. Zhang, X. Wu, S. Jiang, J. Gao, Z. Yao, J. Deng, L. Zhang and Z. Yu, Chem. Commun., 2019, 55, 7187 DOI: 10.1039/C9CC02882J

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