Metal-nucleobase hybrid nanoparticles for enhancing the activity and stability of metal-activated enzymes

Abstract

A novel strategy for enhancing the activity and stability of metal-activated enzymes by allosteric control and confinement of metal-nulceobase hybrid coordination was reported in this study. Despite the lack of active Mg²⁺ ions, methionine adenosyltransferase (MAT) immobilized by Zn₂(adenine) still exhibited robust catalytic activity and stability at pH 3 and 80 °C.