Issue 65, 2019

Click and photo-release dual-functional nucleic acid nanostructures

Abstract

We functionalize nucleic acid nanostructures with click chemistry (for attachment of cargos) and a photocleavable linker (for release). We demonstrate cargo attachment using a fluorescein dye and release using UV trigger from an RNA three-way junction, a DNA star motif and a DNA tetrahedron. Such multifunctional nucleic acid nanostructures have potential in targeted drug delivery.

Graphical abstract: Click and photo-release dual-functional nucleic acid nanostructures

Associated articles

Supplementary files

Article information

Article type
Communication
Submitted
16 May 2019
Accepted
23 Jul 2019
First published
29 Jul 2019

Chem. Commun., 2019,55, 9709-9712

Click and photo-release dual-functional nucleic acid nanostructures

V. A. Valsangkar, A. R. Chandrasekaran, L. Zhuo, S. Mao, G. W. Lee, M. Kizer, X. Wang, K. Halvorsen and J. Sheng, Chem. Commun., 2019, 55, 9709 DOI: 10.1039/C9CC03806J

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