A seesaw ratiometric probe for dual-spectrum imaging and detection of telomerase activity in single living cells

Sujuan Ye; Yingdi Wu; Fuhua Wan; Ying Li

doi:10.1039/C9CC03870A

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A seesaw ratiometric probe for dual-spectrum imaging and detection of telomerase activity in single living cells†

Sujuan Ye,^a Yingdi Wu,^a Fuhua Wan^a and Ying Li

*^a

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* Corresponding authors

^a Key Laboratory of Optic-electric Sensing and Analytical Chemistry for Life Science, MOE, Shandong Key Laboratory of Biochemical Analysis, College of Chemistry and Molecular Engineering, Qingdao University of Science and Technology, Qingdao 266042, P. R. China
E-mail: liying79307@163.com

Abstract

Herein, a seesaw ratiometric (SR) probe is designed which integrates fluorescence and surface enhanced Raman scattering (SERS) technology. Fluorescence imaging enables tracking of the spatiotemporal dynamic behaviour of telomerase. Meanwhile, SERS reverse ratiometric measurement can enable sensitive detection of telomerase activity in single living cells.

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Article information

DOI: https://doi.org/10.1039/C9CC03870A
Article type: Communication
Submitted: 19 May 2019
Accepted: 23 Jul 2019
First published: 25 Jul 2019

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Chem. Commun., 2019,55, 9967-9970

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A seesaw ratiometric probe for dual-spectrum imaging and detection of telomerase activity in single living cells

S. Ye, Y. Wu, F. Wan and Y. Li, Chem. Commun., 2019, 55, 9967 DOI: 10.1039/C9CC03870A

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Chemical Communications

A seesaw ratiometric probe for dual-spectrum imaging and detection of telomerase activity in single living cells†

Abstract

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A seesaw ratiometric probe for dual-spectrum imaging and detection of telomerase activity in single living cells

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