Issue 70, 2019
From the journal:

Chemical Communications

A mitochondria-targeted iridium(iii)-based photoacid generator induces dual-mode photodynamic damage within cancer cells†

Liang He, ORCID logo *ab   Ming-Fang Zhang,b   Zheng-Yin Pan,b   Kang-Nan Wang,b   Zi-Jian Zhao,b   Yi Li ORCID logo c  and  Zong-Wan Mao ORCID logo *ab  

* Corresponding authors

a Department of Applied Chemistry, College of Materials and Energy, South China Agricultural University, Guangzhou 510642, China
E-mail: heliang@scau.edu.cn

b MOE Key Laboratory of Bioinorganic and Synthetic Chemistry, School of Chemistry, Sun Yat-sen University, Guangzhou 510275, China
E-mail: cesmzw@mail.sysu.edu.cn

c Key Laboratory of Theoretical Organic Chemistry and Function Molecule, Ministry of Education, School of Chemistry and Chemical Engineering, Hunan University of Science and Technology, Xiangtan 411201, China

Abstract

A mitochondria-targeted photodynamic therapy (PDT) agent was designed and synthesized. Upon light irradiation, it can produce photoacid and its photolysis products can further sensitize 1O2 generation, causing dual-mode (oxygen-independent and oxygen-dependent) photodynamic damage in mitochondria and killing cancer cells effectively even under hypoxic conditions.

Graphical abstract: A mitochondria-targeted iridium(iii)-based photoacid generator induces dual-mode photodynamic damage within cancer cells

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Article information

DOI
https://doi.org/10.1039/C9CC04871E
Article type
Communication
Submitted
25 Jun 2019
Accepted
05 Aug 2019
First published
05 Aug 2019

Chem. Commun., 2019,55, 10472-10475

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A mitochondria-targeted iridium(III)-based photoacid generator induces dual-mode photodynamic damage within cancer cells

L. He, M. Zhang, Z. Pan, K. Wang, Z. Zhao, Y. Li and Z. Mao, Chem. Commun., 2019, 55, 10472 DOI: 10.1039/C9CC04871E

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