Issue 77, 2019
From the journal:

Chemical Communications

Dual amplification ratiometric biosensor based on a DNA tetrahedron nanostructure and hybridization chain reaction for the ultrasensitive detection of microRNA-133a†

Liping Zhu,a   Jing Ye,a   Shuang Wang,ab   Mengxia Yan,ab   Qiuju Zhu,a   Jianshe Huang ORCID logo *b  and  Xiurong Yang ORCID logo *ab  

* Corresponding authors

a Department of Chemistry, University of Science and Technology of China, Hefei, Anhui 230026, P. R. China

b State Key Laboratory of Electroanalytical Chemistry, Changchun Institute of Applied Chemistry, Changchun, Jilin 130022, China
E-mail: xryang@ciac.ac.cn, huangjs@ciac.ac.cn

Abstract

A novel ratiometric electrochemiluminescence (ECL)–electrochemical (EC) hybrid biosensor with a high accuracy and reproducibility was fabricated for the ultrasensitive detection of miRNA-133a. With the help of a DNA tetrahedron nanostructure and hybridization chain reaction dual amplification strategy, the detection limit of 12.17 aM for miRNA-133a was obtained.

Graphical abstract: Dual amplification ratiometric biosensor based on a DNA tetrahedron nanostructure and hybridization chain reaction for the ultrasensitive detection of microRNA-133a

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Article information

DOI
https://doi.org/10.1039/C9CC05592D
Article type
Communication
Submitted
19 Jul 2019
Accepted
30 Aug 2019
First published
30 Aug 2019

Chem. Commun., 2019,55, 11551-11554

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Dual amplification ratiometric biosensor based on a DNA tetrahedron nanostructure and hybridization chain reaction for the ultrasensitive detection of microRNA-133a

L. Zhu, J. Ye, S. Wang, M. Yan, Q. Zhu, J. Huang and X. Yang, Chem. Commun., 2019, 55, 11551 DOI: 10.1039/C9CC05592D

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