Issue 73, 2019

A biotinylated ruthenium(ii) photosensitizer for tumor-targeted two-photon photodynamic therapy

Abstract

Platinum-resistant cancer cells are sensitive to changes in the levels of reactive oxidative species (ROS). Herein, we design a biotin-modified Ru(II) complex as a photosensitizer (denoted as Ru-Biotin). Ru-Biotin can selectively target cancer cells and produce vast amounts of singlet oxygen under two-photon excitation at 820 nm leading to cell apoptosis. Ru-Biotin is therefore an excellent candidate to overcome platinum resistance via two-photon photodynamic therapy.

Graphical abstract: A biotinylated ruthenium(ii) photosensitizer for tumor-targeted two-photon photodynamic therapy

Supplementary files

Article information

Article type
Communication
Submitted
26 Jul 2019
Accepted
19 Aug 2019
First published
19 Aug 2019

Chem. Commun., 2019,55, 10972-10975

A biotinylated ruthenium(II) photosensitizer for tumor-targeted two-photon photodynamic therapy

J. Li, L. Zeng, K. Xiong, T. W. Rees, C. Jin, W. Wu, Y. Chen, L. Ji and H. Chao, Chem. Commun., 2019, 55, 10972 DOI: 10.1039/C9CC05826E

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