Issue 85, 2019

Multivalent glycoligands with lectin/enzyme dual specificity: self-deliverable glycosidase regulators

Abstract

Multivalent mannosides with inherent macrophage recognition abilities, built on β-cyclodextrin, RAFT cyclopeptide or peptide dendrimer cores, trigger selective inhibition of lysosomal β-glucocerebrosidase or α-mannosidase depending on valency and topology, offering new opportunities in multitargeted drug design.

Graphical abstract: Multivalent glycoligands with lectin/enzyme dual specificity: self-deliverable glycosidase regulators

Supplementary files

Article information

Article type
Communication
Submitted
16 Aug 2019
Accepted
01 Oct 2019
First published
01 Oct 2019
This article is Open Access
Creative Commons BY license

Chem. Commun., 2019,55, 12845-12848

Multivalent glycoligands with lectin/enzyme dual specificity: self-deliverable glycosidase regulators

M. González-Cuesta, D. Goyard, E. Nanba, K. Higaki, J. M. García Fernández, O. Renaudet and C. Ortiz Mellet, Chem. Commun., 2019, 55, 12845 DOI: 10.1039/C9CC06376E

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