Issue 8, 2020

Rational modulation of coumarin–hemicyanine platform based on OH substitution for higher selective detection of hypochlorite

Abstract

To monitor delicate changes of biological HOCl in vivo, a new probe (OH-substituted coumarin–hemicyanine, probe 2) was synthesized for NIR and ratiometric HOCl detection. Selectivity studies indicated that the electron-donating group (OH) substituted on the indolium moiety enhanced the selectivity to detect HOCl. With HOCl, the probe showed a ratiometric fluorescence (I500/I650) with a low detection limit (49.1 nM) and a rapid response (within 2 min). In addition, probe 2 was successfully applied to visualize exogenous and endogenous HOCl in living cells and animals and exhibited a perfect mitochondria target ability. This probe has been further studied as a potential and powerful tool to probe HOCl in arthritis models.

Graphical abstract: Rational modulation of coumarin–hemicyanine platform based on OH substitution for higher selective detection of hypochlorite

Supplementary files

Article information

Article type
Communication
Submitted
21 Aug 2019
Accepted
18 Dec 2019
First published
18 Dec 2019

Chem. Commun., 2020,56, 1219-1222

Rational modulation of coumarin–hemicyanine platform based on OH substitution for higher selective detection of hypochlorite

J. Lan, L. Liu, R. Zeng, Y. Qin, Y. Liu, X. Jiang, A. Aihemaiti, Y. Ding, T. Zhang and R. J. Y. Ho, Chem. Commun., 2020, 56, 1219 DOI: 10.1039/C9CC06477J

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