Half a century of amyloids: past, present and future

Pu Chun Ke; Ruhong Zhou; Louise C. Serpell; Roland Riek; Tuomas P. J. Knowles; Hilal A. Lashuel; Ehud Gazit; Ian W. Hamley; Thomas P. Davis; Marcus Fändrich; Daniel Erik Otzen; Matthew R. Chapman; Christopher M. Dobson; David S. Eisenberg; Raffaele Mezzenga

doi:10.1039/C9CS00199A

Half a century of amyloids: past, present and future†

Pu Chun Ke,

^ab Ruhong Zhou,^cd Louise C. Serpell,

^e Roland Riek,^f Tuomas P. J. Knowles,

^gh Hilal A. Lashuel,ⁱ Ehud Gazit,

^j Ian W. Hamley,

^k Thomas P. Davis,

^bl Marcus Fändrich,^m Daniel Erik Otzen,

ⁿ Matthew R. Chapman,^o Christopher M. Dobson,^g David S. Eisenberg^p and Raffaele Mezzenga

*^qr

Author affiliations

* Corresponding authors

^a Zhongshan Hospital, Fudan University, 111 Yixueyuan Rd, Xuhui District, Shanghai, China

^b ARC Centre of Excellence in Convergent Bio-Nano Science and Technology, Monash Institute of Pharmaceutical Sciences, Monash University, 381 Royal Parade, Parkville, Australia

^c Institute of Quantitative Biology, Zhejiang University, Hangzhou 310058, China

^d Department of Chemistry, Columbia University, New York, New York, USA

^e School of Life Sciences, University of Sussex, Falmer, East Sussex BN1 9QG, UK

^f Laboratory of Physical Chemistry, Department of Chemistry and Applied Biosciences, ETH Zurich, Wolfgang-Pauli-Str. 10, 8093 Zurich, Switzerland

^g Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, UK

^h Cavendish Laboratory, University of Cambridge, J J Thomson Avenue, Cambridge, UK

ⁱ Laboratory of Molecular Neurobiology and Neuroproteomics, Brain Mind Institute, École Polytechnique Fédérale de Lausanne (EPFL), CH-1015 Lausanne, Switzerland

^j Department of Molecular Microbiology and Biotechnology, George S. Wise Faculty of Life Sciences; Department of Materials Science and Engineering, Iby and Aladar Fleischman Faculty of Engineering, Tel Aviv University, 69978 Tel Aviv, Israel

^k School of Chemistry, Food Biosciences and Pharmacy, University of Reading, Whiteknights, Reading RG6 6AD, UK

^l Australian Institute for Bioengineering and Nanotechnology, The University of Queensland, Brisbane, Qld 4072, Australia

^m Institute of Protein Biochemistry, Ulm University, Ulm, Germany

ⁿ Interdisciplinary Nanoscience Center (iNANO) and Department of Molecular Biology and Genetics, Aarhus University, Gustav Wieds Vej 14, 8000 Aarhus C, Denmark

^o Department of Molecular, Cellular and Developmental Biology, Centre for Microbial Research, University of Michigan, Ann Arbor, MI 48109-1048, USA

^p Departments of Chemistry and Biochemistry and Biological Chemistry, UCLA-DOE Institute and Howard Hughes Medical Institute, UCLA, Los Angeles, CA, USA

^q Department of Health Sciences & Technology, ETH Zurich, Schmelzbergstrasse 9, LFO, E23, 8092 Zurich, Switzerland
E-mail: raffaele.mezzenga@hest.ethz.ch

^r Department of Materials, ETH Zurich, Wolfgang Pauli Strasse 10, 8093 Zurich, Switzerland

Abstract

Amyloid diseases are global epidemics with profound health, social and economic implications and yet remain without a cure. This dire situation calls for research into the origin and pathological manifestations of amyloidosis to stimulate continued development of new therapeutics. In basic science and engineering, the cross-β architecture has been a constant thread underlying the structural characteristics of pathological and functional amyloids, and realizing that amyloid structures can be both pathological and functional in nature has fuelled innovations in artificial amyloids, whose use today ranges from water purification to 3D printing. At the conclusion of a half century since Eanes and Glenner's seminal study of amyloids in humans, this review commemorates the occasion by documenting the major milestones in amyloid research to date, from the perspectives of structural biology, biophysics, medicine, microbiology, engineering and nanotechnology. We also discuss new challenges and opportunities to drive this interdisciplinary field moving forward.

Chemical Society Reviews

Half a century of amyloids: past, present and future†

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