Recent advances and prospects in nickel-catalyzed C–H activation

Abstract

Nickel-catalyzed C–H activation has become a predominant and ubiquitous research area in organic chemistry. Direct functionalization of inert C–H bonds to create functionally enriched molecules by rapid elaboration of simple organic substrates in a single step has gained profound interest in recent years. Nickel is an abundant and inexpensive metal widely used in C–H activation by replacing toxic and expensive 4d and 5d transition metals. This review focuses on the recent advances in nickel-catalyzed C–H activation and covers the literature from 2015–2018.