Issue 9, 2019

Anticancer drug delivery to cancer cells using alkyl amine-functionalized nanodiamond supraparticles

Abstract

Nanocarriers have attracted increasing interest due to their potential applications in anticancer drug delivery. In particular, the ability of nanodiamonds (NDs) to spontaneously self-assemble into unique nano-structured architectures has been exploited in the development of nanocarriers. In this context, we synthesized functional supraparticles (SPs) by the self-assembly of alkyl amine-modified NDs for use in anticancer chemotherapy. The structural, physical, and physiological properties of these ND-SPs as well as their high biocompatibility were assessed using microscopic techniques and various characterization experiments. Finally, a model anticancer drug (CPT; camptothecin) was loaded into the ND-SPs to investigate their anticancer efficacy in vitro and in vivo. After incubation of CPT-loaded ND-SPs with cancer cells, a dramatic anticancer effect of ND-SPs was expressed, compared to CPT-loaded ordinary nanocarriers of polyethylene glycol-modified polymer micelles and conventional Intralipid® 20% emulsions containing CPT. Our results demonstrated that ND-SPs may serve as a nanomedicine with significant therapeutic potential.

Graphical abstract: Anticancer drug delivery to cancer cells using alkyl amine-functionalized nanodiamond supraparticles

Supplementary files

Article information

Article type
Paper
Submitted
23 Jul 2019
Accepted
13 Aug 2019
First published
28 Aug 2019
This article is Open Access
Creative Commons BY license

Nanoscale Adv., 2019,1, 3406-3412

Anticancer drug delivery to cancer cells using alkyl amine-functionalized nanodiamond supraparticles

Y. Yu, X. Yang, M. Liu, M. Nishikawa, T. Tei and E. Miyako, Nanoscale Adv., 2019, 1, 3406 DOI: 10.1039/C9NA00453J

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