Issue 21, 2019

A folate-conjugated platinum porphyrin complex as a new cancer-targeting photosensitizer for photodynamic therapy

Abstract

A new folate-conjugated platinum porphyrin complex (Por 4) was synthesized and characterized. The singlet oxygen production of the conjugates was evaluated through a 1,3-diphenylisobenzofuran method. The targeting ability and subcellular localization of Por 4 were confirmed by confocal laser scanning microscopy in HeLa cells (overexpression of FR) as well as in A549 cells (low expression of FR). The results suggested that the modification of the carboxyl group with a porphyrin compound did not decrease the binding affinity of folic acid to FR positive cancer cells. Moreover, the MTT assay using HeLa cells and A549 cells verified the low cytotoxicity of Por 4 in the dark. Upon irradiation, Por 4 showed noticeable improvement in toxicity against cancer cells with the overexpression of FR. Upon the treatment of Por 4 at the concentration of 20 μM, the cell viability was determined as 22% and 75% for HeLa and A549 cells, respectively, indicating that the folate-conjugated platinum porphyrin complex could be a promising PDT agent for cancer with overexpression of the folate receptor.

Graphical abstract: A folate-conjugated platinum porphyrin complex as a new cancer-targeting photosensitizer for photodynamic therapy

Associated articles

Supplementary files

Article information

Article type
Paper
Submitted
26 Mar 2019
Accepted
13 May 2019
First published
13 May 2019

Org. Biomol. Chem., 2019,17, 5367-5374

A folate-conjugated platinum porphyrin complex as a new cancer-targeting photosensitizer for photodynamic therapy

M. Yang, J. Deng, D. Guo, J. Zhang, L. Yang and F. Wu, Org. Biomol. Chem., 2019, 17, 5367 DOI: 10.1039/C9OB00698B

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements