Issue 22, 2019

Recent progress in photochemical radical di- and mono-fluoromethylation

Abstract

Recently, photoinduced radical difluoromethylation has emerged as a step-economical synthetic method of CHF2-containing compounds. In this article, difluoromethylation of alkenes, isonitriles and aryl bromides promoted by photoredox catalysis is described together with a non-catalytic photoinduced system. Representative reactions will be discussed for each highlighted difluoromethylating reagent. In addition, related monofluoromethylation with their corresponding monofluoromethylating reagents is also discussed.

Graphical abstract: Recent progress in photochemical radical di- and mono-fluoromethylation

Article information

Article type
Review Article
Submitted
31 Mar 2019
Accepted
01 May 2019
First published
02 May 2019

Org. Biomol. Chem., 2019,17, 5413-5419

Recent progress in photochemical radical di- and mono-fluoromethylation

T. Koike and M. Akita, Org. Biomol. Chem., 2019, 17, 5413 DOI: 10.1039/C9OB00734B

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements