Issue 30, 2019

Dinuclear zinc cooperative catalytic three-component reactions for highly enantioselective synthesis of 3,3′-dihydrofuran spirooxindoles

Abstract

A new dinuclear zinc cooperative catalytic enantioselective three-component reaction via a domino Knoevenagel /Michael/cyclization sequence has been developed. A series of chiral 3,3′-dihydrofuran spirooxindoles are obtained in excellent yields (up to 99%) and enantioselectivities (up to 99% ee). In addition, the reaction is carried out smoothly on a gram scale under mild conditions.

Graphical abstract: Dinuclear zinc cooperative catalytic three-component reactions for highly enantioselective synthesis of 3,3′-dihydrofuran spirooxindoles

Supplementary files

Article information

Article type
Paper
Submitted
28 May 2019
Accepted
09 Jul 2019
First published
10 Jul 2019

Org. Biomol. Chem., 2019,17, 7172-7181

Dinuclear zinc cooperative catalytic three-component reactions for highly enantioselective synthesis of 3,3′-dihydrofuran spirooxindoles

Y. Miao, Y. Hua and M. Wang, Org. Biomol. Chem., 2019, 17, 7172 DOI: 10.1039/C9OB01233H

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