Transition-metal-free decarboxylative C3-difluoroarylmethylation of quinoxalin-2(1H)-ones with α,α-difluoroarylacetic acids

Abstract

A facile transition-metal-free decarboxylative radical coupling reaction of α,α-difluoroarylacetic acids with quinoxalin-2(1H)-ones has been developed. This methodology provided a highly attractive approach to synthesize a series of difluoroarylmethylated quinoxalin-2(1H)-ones that contain various functional groups in moderate to good yields under mild conditions. Moreover, experimental studies reveal that the CF₂ group of α,α-difluoroarylacetic acids plays a vital role in this transformation.