Issue 41, 2019

Functionalized gold nanostructures: promising gene delivery vehicles in cancer treatment

Abstract

Surface-modified gold nanoparticles are recognized as promising gene delivery vehicles in the treatment of cancer owing to their excellent biocompatibility with biomolecules (like DNA or RNA) and their unique optical and structural properties. In this context, this review article focuses on the diverse transfection abilities of the gene to the targeted cell on the basis of different shapes and sizes of gold nanoparticles in order to promote its effective expression for cancer treatment. In addition, recent trends in gold nanoparticle mediated gene silencing, gene delivery, detection and combinatory therapies are highlighted considering their cytotoxic effects on healthy human cells.

Graphical abstract: Functionalized gold nanostructures: promising gene delivery vehicles in cancer treatment

Article information

Article type
Review Article
Submitted
14 May 2019
Accepted
19 Jul 2019
First published
01 Aug 2019
This article is Open Access
Creative Commons BY-NC license

RSC Adv., 2019,9, 23894-23907

Functionalized gold nanostructures: promising gene delivery vehicles in cancer treatment

S. Kumar, A. Diwan, P. Singh, S. Gulati, D. Choudhary, A. Mongia, S. Shukla and A. Gupta, RSC Adv., 2019, 9, 23894 DOI: 10.1039/C9RA03608C

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