Issue 48, 2019, Issue in Progress

A restricted access molecularly imprinted polymer coating on metal–organic frameworks for solid-phase extraction of ofloxacin and enrofloxacin from bovine serum

Abstract

A restricted access molecularly imprinted polymer (RAMIP) crosslinked with bovine serum albumin (BSA) was prepared on the surface of the mesoporous UiO-66-NH2 metal–organic framework (MOF). The surface morphology, imprinting behavior, and protein exclusion properties of UiO-66-NH2@RAMIP@BSA were investigated. The maximum adsorption capacity was 50.55 mg g−1 for ofloxacin, with a 99.4% protein exclusion rate. Adsorption equilibrium was reached in 9 min. Combined with RP-HPLC, a solid-phase extraction column filled with UiO-66-NH2@RAMIP@BSA was used to selectively enrich and analyze ofloxacin and enrofloxacin antibiotics from bovine serum with recoveries of 93.7–104.2% with relative standard deviations of 2.0–4.5% (n = 3). The linear range and the limit of detection were 0.1–100 μg mL−1 and 15.6 ng mL−1, respectively. These results suggest that UiO-66-NH2@RAMIP@BSA is an efficient pretreatment adsorbent for biological sample analysis.

Graphical abstract: A restricted access molecularly imprinted polymer coating on metal–organic frameworks for solid-phase extraction of ofloxacin and enrofloxacin from bovine serum

Supplementary files

Article information

Article type
Paper
Submitted
01 Jun 2019
Accepted
02 Sep 2019
First published
04 Sep 2019
This article is Open Access
Creative Commons BY-NC license

RSC Adv., 2019,9, 27953-27960

A restricted access molecularly imprinted polymer coating on metal–organic frameworks for solid-phase extraction of ofloxacin and enrofloxacin from bovine serum

Z. Sun, H. Liu, Y. Zhou, S. Zhao, J. Li, X. Wang and B. Gong, RSC Adv., 2019, 9, 27953 DOI: 10.1039/C9RA04143E

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