Issue 72, 2019, Issue in Progress

Access to 1-amino-3,4-dihydroisoquinolines via palladium-catalyzed C–H bond aminoimidoylation reaction from functionalized isocyanides

Abstract

Efficient access to 1-amino-3,4-dihydroisoquinolines, through palladium-catalyzed intramolecular C–H bond aminoimidoylation of α-benzyl-α-isocyanoacetates, has been developed. Consecutive isocyanide insertion and C–H bond activation were realized with C–N and C–C bonds formation in one step under redox neutral conditions, employing O-benzoyl hydroxylamines as electrophilic amino sources.

Graphical abstract: Access to 1-amino-3,4-dihydroisoquinolines via palladium-catalyzed C–H bond aminoimidoylation reaction from functionalized isocyanides

Supplementary files

Article information

Article type
Paper
Submitted
05 Nov 2019
Accepted
12 Dec 2019
First published
18 Dec 2019
This article is Open Access
Creative Commons BY-NC license

RSC Adv., 2019,9, 42072-42076

Access to 1-amino-3,4-dihydroisoquinolines via palladium-catalyzed C–H bond aminoimidoylation reaction from functionalized isocyanides

Z. Xiong, P. Cai, Y. Mei and J. Wang, RSC Adv., 2019, 9, 42072 DOI: 10.1039/C9RA09139D

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